When you think of Big Ten college football, the Michigan State Spartans would be on the short list of teams that come to mind. For the full slate of college football matchups, check out our college football odds board! Claim the FanDuel Sportsbook promo code offer to get up to $3,000 in bonus bets. Michigan State stumbled late in the year, losing to Michigan in its regular season finale and then falling to UCLA in the Big Ten Tournament, but Tom Izzo has his players firing on all cylinders in the NCAA Tournament. Duke, though, is even better defensively, holding teams under 60 points per game.

Betting on Michigan State football remains a major draw in season through legal wagers on in-state college teams. If the betting line is set at 45 points, these two teams would have to score a combined 46 points or more to produce a winning bet on the OVER. A popular way to bet on the Michigan State vs. Michigan game is using the college football total line for combined points scored. In-state bragging rights are always on the line when those two teams face off against one another each season. The Spartans have won the Big Ten Championship nine times during their tenure in the conference. The highlight of that extended timeframe was the team’s first national title run in that final season.

The Spartans, while a soid team, have dropped 2 of their last 4 and nearly fell in the second round in a battle with Louisville. Karaban has scored 49 points in the first 2 games and Reed has 41 points and 40 rebounds in 2 tourney games. F Coen Carr scored a game-high 21 points with 10 rebounds, while G Jeremy Fears Jr. also had a double-double with 12 points and 16 assists.

For now, though, all focus remains on the Spartans, a team that is 2-2 (0-1). If Camp Randall Stadium doesn't support this team after they just took down the Nittany Lions, what will it take to get Luke Fickell and Co. back on track? This Week 5 matchup is important for numerous reasons, but none more than the fact that it's UW's 2026 Big Ten home opener. After upsetting Penn State, it comes as no surprise that the Wisconsin Badgers are massive favorites against Michigan State. Stay up to date on all things Huskers by bookmarking Nebraska Cornhuskers On SI, subscribing to HuskerMax on YouTube, and visiting HuskerMax.com daily.

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• Duke, though, is even better defensively, holding teams under 60 points per game.

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Florida vs Norfolk State NCAA Tournament odds:

This top-ranked Notre Dame defense should be able to hold down a Michigan State offense that's only faced Toledo and Eastern Michigan. Notre Dame has only allowed 13 total points to kick off the 2026 season, with all that coming against Wisconsin in Week 1. The Under correlates with backing the Spartans, plus Notre Dame doesn't allow anyone to score, so points should come at a premium in this matchup. With Notre Dame's first two tests coming against Rice and Wisconsin, any top-five ranked team should have won those games by a combined 80 points. My Week 3 college football picks outline why the Spartans should keep it within the 29.5-point spread, even though Notre Dame carries a 97% win probability.

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Jacobs will have nearly an entirely new roster to work with — Toledo retains just 17% of its total snaps from last season. New boss Mike Jacobs was the head coach at FCS team Mercer for the past two campaigns. Here's a closer look at the college football betting landscape for Michigan State vs. Toledo at the best betting apps, with some notes on what bettors should keep in mind for this matchup.

NFL HUSKERS

The Spartans return just 24% of their production, have 48 new players and turn the offense over to Weaver, who has 6 career TD passes against 7 turnover-worthy plays. The Spartans are 10-point favorites at home, per the latest DraftKings Sportsbook odds, and the Over/Under for total points scored is 48.5. While both of these teams are set to meet again later this season, this game will have huge implications for who wins the conference. Michigan State's losses this season have both come against top 10 teams.

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